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Data extraction was done independently by two reviewers (KT and TA) and disagreements were resolved by discussion

Data extraction was done independently by two reviewers (KT and TA) and disagreements were resolved by discussion. Methodological Quality Assessment For the RCTs, we assessed the adequacy of the methods used for randomization, allocation concealment, blinding, and follow-up [22,23]. The numerator is the number of patients who developed resistance, and the denominator is the number […]