eIF2B is a decameric guanine nucleotide exchange factor with a 22 tetrameric core
eIF2B is a decameric guanine nucleotide exchange factor with a 22 tetrameric core. in a decreased shuttling of eIF2. Interestingly, drugs that inhibit the ISR can rescue eIF2 shuttling in a manner correlating to levels of eIF2-P. In contrast, smaller bodies show increased eIF2 shuttling in response to stress, which is accompanied by the localization […]