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Given the reduced response rate to Multi-targeted TKIs in RET-rearranged NSCLC, the next-generation RET-selective inhibitors, RXDX-105, BLU-667, and LOXO-292, are getting tested

Given the reduced response rate to Multi-targeted TKIs in RET-rearranged NSCLC, the next-generation RET-selective inhibitors, RXDX-105, BLU-667, and LOXO-292, are getting tested. RXDX-105 is a VEGFR-sparing potent RET inhibitor. rising agencies and ongoing scientific research. = 14). The median PFS was 8.1?a few months in all sufferers, 9.5?a few months in T790M-positive sufferers, and 5.4?a […]