Nature 441, 235C238 (2006). Moreover, inhalation of enterotoxin A induced IL-2 secretion and caspase-1-dependent IL-1 activation to drive IL-17 production. This T-cell-mediated inflammasome-dependent IL-17 response is maximum when lung T17 cells were sequentially stimulated first with IL-2 then IL-1. Interestingly, when IL-2 is given therapeutically to cancer patients it carries a known risk of lung […]

HMPV (clinical strain TN/94-49, subtype A2) and influenza computer virus (strain HK/x31, H3N2) were grown and titered in LLC-MK2 or MDCK cells while previously described(1, 31). T cell figures. Mechanistically, Treg depletion during immune priming led to impaired dendritic cell and CD8+ T cell migration. Further, early Treg depletion was associated with immune skewing towards […]