E1A activates transcription of Noxa and p73 to induce apoptosis
E1A activates transcription of Noxa and p73 to induce apoptosis. in mitochondria, resulting in cytochrome discharge. Importantly, cytochrome apoptosis and discharge were reduced in Bax/Bak one or double-knockout BMK cells. Furthermore, overexpression of Bcl-2 could ameliorate cisplatin-induced cytochrome apoptosis and discharge. Together, the outcomes have confirmed a p53-indie system of cisplatin nephrotoxicity which involves the […]