2012; 125:2732C2739. of ribosomal RNA (rRNA) synthesis, in both cancer and regular cells. We demonstrate that Che-1 interacts with RNA polymerase I and nucleolar upstream binding aspect (UBF) and promotes RNA polymerase I-dependent transcription. Furthermore, this proteins binds towards the rRNA gene (rDNA) promoter and modulates its epigenetic condition by contrasting the recruitment of HDAC1. […]