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We previously identified a hematopoietic stem and progenitor cell (HSPC)-specific silencer element (the methylation-determining region [G1MDR]) that recruits DNA methyltransferase 1 (Dnmt1) and provokes methylation of the gene enhancer

We previously identified a hematopoietic stem and progenitor cell (HSPC)-specific silencer element (the methylation-determining region [G1MDR]) that recruits DNA methyltransferase 1 (Dnmt1) and provokes methylation of the gene enhancer. apoptosis of HSPCs. Furthermore, genetic deletion of in HSPCs activated expression and depleted HSPCs, thus recapitulating the HSC phenotype associated with GATA1 gain of function. These […]